Margery was born in about 1478, and was the mother to Jane,Elizabeth,Thomas and Edward. On 22 October 1494 Margery married Sir John Seymour (1476 – 21 December 1536) On the same day, her father Henry remarried Lady Elizabeth Scrope.
Margery and her husband had ten children together
- John Seymour (died 15 July 1510)
- Edward Seymour, 1st Duke of Somerset, Lord Protector of Edward VI (c. 1500 – 22 January 1552) married firstly Katheryn Filliol and secondly Anne Stanhope.
- Sir Henry Seymour (1503–1578)
- Thomas Seymour, 1st Baron Seymour of Sudeley (c. 1508 – 20 March 1549) married Catherine Parr, widow of King Henry VIII.
- John Seymour (died young)
- Anthony Seymour (died c. 1528)
- Jane Seymour, (c. 1509 – 24 October 1537). queen consort of King Henry VIII and the mother of Edward VI.
- Margery Seymour (died c. 1528)
- Elizabeth Seymour (c. 1518 – 19 March 1568)
- Dorothy Seymour (c. 1515 – 26 August 1552)